Robust Stability of the Embryonic Axial Pattern Requires a Secreted Scaffold for Chordin Degradation
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چکیده
منابع مشابه
Robust Stability of the Embryonic Axial Pattern Requires a Secreted Scaffold for Chordin Degradation
Dorsal axial formation during vertebrate embryogenesis exhibits robust resistance to perturbations in patterning signals. However, how such stability is supported at the molecular level remains largely elusive. Here we show that Xenopus ONT1, an Olfactomedin-class secreted protein, stabilizes axial formation by restricting Chordin activity on the dorsal side. When ONT1 function is attenuated, t...
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ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.07.008